Neem (Azadirachta indica) is an evergreen tree with a well-earned reputation for being the most potent medicinal flora in the world.

The neem tree is known in Ayurveda as nature's pharmacy.

The tree grows predominantly in the Indian subcontinent but is now being cultivated in similar climates all over the world as people are beginning to recognize its usefulness.

All parts of the neem tree are used: leaves, bark, root and fruits.

ABSTRACT

Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant.

It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases.

Earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis.

The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-κB, PI3K/Akt, Bcl-2, and VEGF.

It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect.